 | Term | Definition |
| |
Inflammatory Response |
It is nonspecific because it takes place the same way regardless of the stimulus |
| |
Swelling |
Tumor |
| |
Redness |
Rubor |
| |
Heat |
Calor |
| |
Pain |
Dolar |
| |
Chronic Inflammation |
Persists for more than two weeks |
| |
Neutrophil |
First at the Injury site, ingest bacteria, dead cells, and cellular debris and then dies and is removed as pus.Short lived and principle role is to remove debris from sterile lesion.Main cell in early inflammation. |
| |
Monocytes and Macrophages |
Perform same functions as Neutrophils but for a longer time. Monocyte largest normal blood cell. |
| |
The Mast Cell |
Develop in bone marrow, they mature in tissues and contains granules. Activate Inflammatory response by degranulation and the release of histamine. |
| |
Degranulation of Mast Cell |
stimulated by injury, chemical agents such as bee venom, immunologic, and activation of complement components |
| |
Histmaine |
Causes increased blood flow to the microcirculation via postcapillary dilation and the constriction of blood vessel muscle (squeeze) |
| |
Esoinophils |
Control intensity of the inflammatory response. * Mediators of acute inflammation released by Mast Cells |
| |
Leukotrienes and Prostaglandins |
mediators synthesized from arachidonic acid, which is released from the mast cell membrane |
| |
Complement System |
most improtant of the plasma protein systems of inflammation because its components participate in virtually every aspect of inflammatory response |
| |
C5 TO C9 |
Componets that form Membrane Attack Complexes (MAC) which punch holes in a target cell's rigid out membrane |
| |
Margination |
Phagocytes stick tightly to caplillary and venule walls |
| |
Diapedesis |
Phagocytes emigrate through the retracting endothelial junctions and out into the surrounding tissues |
| |
Phagocytosis |
Begins when cells enters inflammatory site, the phagocyte binds to the opsonized bacteria tightly. Opsonins become "glue" (site is Fc receptor) |
| |
Phagosome |
An intracellular phagocytic vacuole. Formed by engulfment carried out by pseudopods on the membrane. |
| |
Hydrogen Peroxide |
The principle oxygen-dependent killing mechanism of phagocytosis |
| |
Macrophage |
Survives acidic inflammatory site. It can fuse into larger cells called giant cells capable of phagocytosing larger targets. |
| |
Serous Exudate |
Watery, fluid in a blister |
| |
Epithelialization |
Process by which epithelial cells grow into the wound surrounding the tissues |
| |
Fibroblasts |
The most important cells during the reconstructive phase of wound healing because they synthesize collagen. Forms scar tissue. |
| |
Dehiscence |
Wound pulls away from suture line |
| |
Sequence of Phagocytosis |
margination,diapedesis, recognition, adherence, ingestion, fusion wiht lysosomes inside the phagocyte, destruction of the traget cell. |
| |
Repiar |
1. Fill in the wound 2.Cover or seal the wound 3. Shrink the wound |
Share on Facebook
Share on MySpace